C014 Doxazosin-stimulated apoposis in left ventricules of spontaneously hypertensive rats
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چکیده
منابع مشابه
β3-adrenoceptors inhibit stimulated norepinephrine release in spontaneously hypertensive rats
Here, the influence of β3-adrenoceptors on catecholamine release in normotensive and spontaneously hypertensive rats was analyzed. Blood pressure was recorded through a femoral artery catheter, and cardiac output by ascending aorta flow. Time from onset of flow to maximum rise in flow indicated inotropy. Total peripheral vascular resistance (TPR) was calculated. Norepinephrine release was stimu...
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We evaluated the effects of treatment for 12 weeks with 10 mg/kg/day of either losartan or doxazosin on vascular function in senescent spontaneous hypertensive rats (SHR). Both doxazosin and losartan reduced blood pressure, although the former was more effective. In contrast, both drugs reduced relative aortic weight and increased plasma nitrates to a similar extent. Losartan, but not doxazosin...
متن کاملLeft ventricular hypertrophy improves cardiac function in spontaneously hypertensive rats.
1. The influence of different arterial pressures on the relationship between diastolic filling pressure and stroke volume was studied during pharmacological cardiac nerve blockade in adult, anaesthetized spontaneously hypertensive rats in comparison with matched normotensive Wistar--Kyoto rats. 2. Peak stroke volumes, obtained by rapid blood volume expansion were similar in both types of rat, d...
متن کاملSpontaneously Hypertensive Rats
We have investigated whether differences seen in the pharmacological and morphological properties of mesenteric resistance vessels from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) controls are also present in vessels from young SHR and WKY rats in which there is little difference in blood pressure (BP). Segments of small arteries (lumen diameter 150 ̂ m) were taken ...
متن کاملSpontaneously Hypertensive Rats
The endothelium-dependent vascular relaxation to acetylcholine (ACh) in spontaneously hypertensive rats (SHR) may be impaired because of an imbalance of endothelium-derived relaxing factor and contracting factor. However, the role of the endothelium-dependent hyperpolarization remains undetermined. We examined the ACh-induced hyperpolarization and its contribution to relaxation in arteries of S...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1998
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(97)91047-5